United States: Pharmacokinetic Differences Corroborate Observed Low Tacrolimus Dosage In Native ...

United States: Pharmacokinetic Differences Corroborate Observed Low Tacrolimus Dosage In Native American Renal Transplant Patients Anita Grover, Lynda A. Frassetto, Leslie Z. Benet, and Harini A. Chakkera, 2011   We have observed in clinical practice that Native Americans require lower dosages of tacrolimus to attain similar target blood trough levels as compared to Caucasians following renal transplant. Because there are no pharmacokinetic studies of tacrolimus in this ethnic group, we...

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